اثر تحریک الکتریکی مستقیم شکنج پیشانی تحتانی راست مغز بر بهبود بازداری در افراد دارای نشانگان نقص‌توجه و بیش فعالی

نوع مقاله: مقاله پژوهشی

نویسندگان

1 1. کارشناس ارشد، روانشناسی بالینی کودک و نوجوان، دانشکده روان‌شناسی، دانشگاه شهید بهشتی، تهران، ایران.

2 2. استادیارعلوم اعصاب شناختی، گروه روانشناسی، دانشگاه شهید بهشتی. تهران، ایران.

3 3. عضو هیات علمی پژوهشکده علوم شناختی، تهران، ایران

چکیده

مقدمه و اهداف
در افراد مبتلا به نقص­توجه و بیش­فعالی، کنترل مهاری که به معنای توانایی کنترل رفتارها یا پاسخ­های نامناسب و یکی از مؤلفه­های اصلی کارکرد اجرایی است، دچار نقص است. هدف از مطالعه حاضر بهبود توانایی بازداری از طریق تحریک الکتریکی مستقیم از روی جمجمه (tDCS) بر روی افراد دارای نشانگان نقص­توجه و بیش­فعالی است.
مواد و روش ها
در این پژوهش20 نفر از دانش­آموزان هنرستان سیدالشهداء استان کرمان از طریق پرسشنامه­های وندریوتا و کانرز که نشانگان اختلال نقص­توجه و بیش­فعالی را در بزرگسالی و کودکی می­سنجند، انتخاب شدند. همچنین از پرسشنامه SCL-25 برای سنجش سلامت عمومی روانی آزمودنی­ها استفاده شد. آزمودنی­ها در موقعیت تحریک آند و شرایط شبه تحریک از طریق آزمون­های استروپ و برو/ نرو که برای سنجش کنترل مهاری هستند مورد ارزیابی قرار گرفتند.
یافته ها
نتایج نشان می­دهد تحریک آند بر روی شکنج پیشانی تحتانی راست، دقت مهار را در مرحله اجرای مهار محرک­های هدف پیشین به­طور معناداری افزایش می­دهد.
بحث و نتیجه گیری
تحریک الکتریکی مستقیم از روی جمجمه بر روی شکنج پیشانی تحتانی راست (rIFG) افراد دارای نشانگان نقص­توجه و بیش­فعالی، می­تواند کنترل مهاری را در مهار محرک­های هدف پیشین بهبود ببخشد.

کلیدواژه‌ها


عنوان مقاله [English]

Effect of transcranial Direct Current Stimulation on Remediation of Inhibitory Control on right Inferio Frontal Gyrus in Attention Deficit and Hyperactivity Symptoms

نویسندگان [English]

  • Zahra Soltaninejad 1
  • Vahid Nejati 2
  • Hamed Ekhtiari 3
1 1. Master of Child and Adolescent Clinical Psychology, Shahid Beheshti University, Tehran, Iran.
2 2. Assisstant Professor,Department of Cognitive Neuroscience, Faculty of psychology, Shahid Beheshti University, Tehran, Iran.
3 3. MD, Institute for cognitive sciences studies (ICSS), Tehran, Iran
چکیده [English]

Background and Aim: Inhibitory control which is defined as the ability to control the improper responses or behaviors is one of the main components of executive function. Its deficiency in people who have Attention deficit and hyperactive disorder has been shown. The purpose of this study was to improve inhibitory control through transcranial direct current stiFmulation (TDCS) in people with attention deficit and hyperactive disorder syndrome.  
Materials and Methods: In this study, 20 technical school students were selected through Wender Utah Rating Scale and CAARS questionnaires which measure attention deficit and hyperactive disorder syndrome in childhood and adulthood as well as SCL-25 questionnaire which measures general psychological health. All the subjects were tested by Stroop and Go-no-Go tests which measure inhibitory control, under anodal stimulation, and sham conditions.
Results: The findings show that anodal stimulation on right Inferio Frontal Gyrus increases the accuracy of inhibition in prepotent stimulus inhibition stage significantly.
Conclusion: TDCS on right Inferio Frontal Gyrus of the people with attention deficit and hyperactive disorder syndrome can improve the inhibitory control in prepotent stimulus inhibition.

کلیدواژه‌ها [English]

  • Transcranial direct current stimulation (TDCS)
  • Inhibitory control
  • attention deficit and hyperactive disorder
  1. American Psychiatric Association. DSM-IV-TR: Diagnostic and statistical manual of mental disorders. 4th  edition. Text revision. Washington, DC: American Psychiatric Association; 2000. P. 355-356. [In Persian].##
  2. Gomez R, Hafetz N. DSM-IV ADHD: Prevalence based on parent and teacher ratings of Malaysian primary school children. Asian Journal of Psychiatry. 2011; 4(1): 41-44.##
  3. Luman  M, Tripp G, Scheres A. Identifying the neurobiology of altered reinforcement sensitivity in ADHD: A review and research agenda. Neuroscience and Biobehavioral Reviews. 2010; 34(5): 744-754.##
  4. Goldstin S, Naglieri J. A. The school Neuropsychology of ADHD: theory, assessment and intervention. Psychology in the school. 2008; 45(9): 859-874.##
  5. Dick D. M, Smith G, Olausson  P, Mitchell S. H, Leeman R. F, O'Malley S, et al. Understanding the construct of impulsivity and its relationship to alcohol use disorders. Addiction Biology. 2010; 15(2): 217-226.##
  6. Depue  B. E, Burgess G. C, Willcutt  E. G, Ruzic L, Banich M. T. Inhibitory control of memory retrieval and motor processing associated with the right lateral prefrontal cortex: Evidence from deficits in individuals with ADHD. Neuropsychologia. 2010; 48(13): 3909-3917.##
  7. Vaidya CJ, Austin G, Kirkorian G, Ridlehuber HW, Desmond JE, Glover GH, et al. Selective effects of methylphenidate in attention deficit hyperactivity disorder: a functional magnetic resonance study. Proc Natl Acad Sci USA. 1998; 95(24): 14494-9.##
  8. Overtoom CC, Kenemans JL, Verbaten MN, Kemner C, van der Molen MW, van EH, et al. Inhibition in children with attention-deficit/hyperactivity disorder: a psychophysiological study of the stop task. Biol Psychiatry. 2002; 51(8): 668-76.##
  9. Nejati V, shiri E. Neurocognitive evidence for deficit in inhibitory control and risky decision making in smokers. Journal of Research in Behavioural Sciences. 2013; 11(1): 1-9 [In Persian].##
  10.  Brunoni A. R, Nitsche M. A, Blognini N, Bikson M, Wagner T, Merabet L, et al. Clinical research with transcranial direct current stimulation (tDCS): Challenges and future directions. Brain Stimulation. 2012; 5(3): 175-195.##
  11.  Dasilva  A. F, Volz  M. S, Bikson  M, Fregni  F. Electrode Positioning and Montage in Transcranial Direct Current Stimulation. 2011. RACGP Online. Available at: URL:  http://www.jove.com/pdf/2744/jove-protocol-2744-electrode-positioning-montage-transcranial-direct-current. Accessed Mar 15, 2013.##
  12.  Utz  K. s, Dimova  V, Oppenlander  K, Kerkhoff  G. Electrified minds: Transcranial direct current stimulation (tDCS) and Galvanic Vestibular Stimulation (GVS) as methods of non-invasive brain stimulation in neuropsychology- A review of current data and future implications. Neuropsychologia. 2010; 48(10): 2789- 2810.##
  13.  Sarrami Froshani Pooria. Validity and Reliability of “Wender Utah Test” to detect “Attention-deficit Hyperactivity Disorder” in Adult in Isfahan. [PhD Dissertation]. Isfahan:  Isfahan University of Medical Sciences; 2000. [In Persian]##
  14.  Conners, C.K., Erhardt, D., Sparrow, E. Conners' Adult ADHD Rating Scales (CAARS) technical manual. N.Tonawanda, NY: Multi-Health Systems; 1999.##
  15.  Fregni  F, Pascual-Leone, A. Technology insight: noninvasive brain stimulation in neurology-perspectives on the therapeutic potential of rTMS and tDCS. Nat Clin Pract Neurol. 2007; 3(7): 383-393.##
  16.  Ditye T, Jacobson  L, Walsh  V, Lavidor  M. Modulating behavioral inhibition by tDCS combined with cognitive training. Exp Brain Res. 2012; 219(3): 363-368.##
  17.  Gubillo  A, Halari  R, Ecker  C, Giampietro  V, Taylor  E, Rubia  K. Reduced activation and inter-regional functional connectivity of fronto-striatal networks in adults with childhood Attention-Deficit Hyperactivity Disorder (ADHD) and persisting symptoms during tasks of motor inhibition and cognitive switching. Journal of Psychiatric Research 2010; 44(10): 629-639.##
  18.  Hsu T.Y, Tseng  L. Y, Yu  J. X, Kuo W. J, Hung  D, et al. Modulating inhibitory control with direct current stimulation of the superior medial frontal cortex. NeuroImage. 2011; 56(4): 2249-2257##
  19.  Liotti M, Pliszka S. R, Higgins K, Perez III R, Semrud-Clikeman M. Evidence for specificity of ERP abnormalities during response inhibition in ADHD children: A comparison with reading disorder children without ADHD. Brain and Cognition. 2010; 72(2): 228-237.##
  20.  Woltering  S, Liu Z, Rokeach A, Tannock  R. Neurophysiological differences in inhibitory control between adults with ADHD and their peers. Neuropsychologia. 2013; 51(10): 1888-1895.##
  21.  Moser  S, Cuini  S, Weber  P, Schroeter  M. L. Right prefrontal brain activation due to Stroop interference is altered in attention-deficit hyperactivity disorder- A functional near-infrared spectroscopy study. Psychiatry Research: Neuroimagin. 2009; 173(3): 190-195.##
  22.  Yasumura  A, Kokubo  N, Yamamoto  H, Yasumura Y, Nakagawa  E, Kaga  M, Hiraki  K, Inagaki M. Neurobehavioral and hemodynamic evaluation of Stroop and reverse Stroop interference in children with attention-deficit/hyperactivity disorder. Brain and Development. 2014; 36(2): 97-106.##
  23.  Ikeda Y, Okuzumi H, Kokubun M. Stroop/reverse-Stroop interference in typical development and its relation to symptoms of ADHD. Research in Developmental Disabilities. 2013; 34(8): 2391-2398.##