توانمندی مولکول هیدروژن در کاربردهای پیشگیری و درمانی در کم شنوایی ناشی از نویز

نوع مقاله : مقاله پژوهشی

نویسندگان

1 1. متخصص، گوش و حلق و بینی و دانشیار دانشگاه علوم پزشکی ایران. تهران، ایران

2 2. دانشجوی دکترای تخصصی شنوایی شناسی، دانشکده توانبخشی دانشگاه علوم پزشکی ایران، تهران، ایران

3 3. کارشناس شنوایی شناسی، دانشگاه علوم پزشکی تهران

10.22037/jrm.2013.1100134

چکیده

مقدمه و اهداف
استرس اکسیداتیو حاد بطور مستقیم منجر به ضایعه جدی در بافت ها می شود. علی رغم اهمیت کلینیکی ضایعه اکسیداسیون، آنتی اکسیدان ها (مواد ضد اکسیداسیون) دارای موفقیت درمانی محدودی هستند. مولکول هیدروژن با قابلیت نفوذ گازی و سریع خود قادر به نفوذ به درون غشاهای زیستی و انتشار به درون سیتوپلاسم می باشد. علاوه بر این هیدروژن می تواند از طریق سد خونی  مغز که مانعی برای عبور بسیاری از آنتی اکسیدان ها است، عبور کند و این مزیت مولکول هیدروژن، ضرورت انجام این مطالعه را روشن می سازد. هدف از مطالعۀ حاضر بررسی نتایج پژوهش‏های انجام شده پیرامون مولکول هیدروژن به عنوان یک آنتی اکسیدان "جدید" بود.
مواد و روش ها
در این مقاله پژوهش‏هایی که به بررسی مولکول هیدروژن و تأثیر آن بر سیستم شنوایی پرداخته بودند، مرور شد. این مطالعات با کلید واژه‎های رادیکال آزاد و مولکول هیدروژن از بانک‎های اطلاعاتی Medline، Google Scholar، PubMed و SID از سال 1973 تا 2012 استخراج شدند.
نتیجه گیری
مولکول هیدروژن به عنوان یک آنتی اکسیدان دارای فواید بالقوه بسیار زیاد از جمله انتشار سریع به درون بافت ها و سلول ها است و همچنین مولکول هیدروژن هیچ کدام از واکنش های متابولیک اکسیداسیون و احیا و رادیکال های آزاد موثردر سیگنالینگ سلول را تحت تاثیر قرار نمی دهد و مکانیسم اثر خود را از طریق کاهش آنزیم های درگیر در روند آپوپتوزیس و التهاب اعمال می کند.

کلیدواژه‌ها


عنوان مقاله [English]

Capabilities of hydrogen Molecules for use in the prevention and treatment in noise induced hearing loss

نویسندگان [English]

  • Abdollah Moossavi 1
  • Fereshte Bagheri 2
  • Hamid Ramezani Farkhani 3
1 1. ENT, Associate Professor of Iran University of Medical Science Tehran, Iran
2 2. Phd student of Audiology, Faculty of Rehabilitation, Iran University of Medical Sciences, Tehran, Iran
3 3. Bs of Audiology, Tehran University of Medical Sciences, Tehran, Iran (Corresponding Author)
چکیده [English]

Background and Aim: Acute oxidative stress directly contributes to tissue injury. Hydrogen molecule with the rapid penetration is able to penetrate the biomembranes and diffuse into the cytosol. Moreover, H2 passes through the blood brain barrier, although most antioxidant compounds cannot; this is also an advantage of H2. The aim of this article was to review the literature regarding the effect of hydrogen molecule on auditory system.
Material & Methods: We searched Medline, Google Scholar, PubMed and SID search engines with the "antioxidant" and "hydrogen" keywords and read textbooks about this subject between 1973 and 2012.
Conclusion:  Hydrogen molecule as an antioxidant potentially has numerous benefits including rapid diffusion into tissues and cells. Also it is mild enough neither to disturb metabolic redox reactions nor to affect reactive oxygen species that function in cell signaling and the action mechanism of hydrogen molecule is performed via decrease of the enzymes involved in apoptosis and inflammation.

کلیدواژه‌ها [English]

  • Oxidative stress
  • Antioxidant
  • free radical
  • Blood brain barrier
  • Hydrogen molecule
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