Shahid Beheshti University of Medical Sciences The Scientific Journal of Rehabilitation Medicine 2251-8401 12 4 2023 09 23 Effect of Repetitive Transcranial Magnetic Stimulation on the Working Memory of Patients with Alzheimer’s Disease Effect of Repetitive Transcranial Magnetic Stimulation on the Working Memory of Patients with Alzheimer’s Disease 790 801 1101692 10.32598/SJRM.12.4.15 FA Mohsen Saeidmanesh Department of Psychology, Science and Arts University, Yazd, Iran 0000-0003-4984-3343 Mahya Shabanzadeh Department of Clinical Psychology, Islamic Azad University, Anar, Iran 0000-0001-9209-7548 Mahsa Moslemi Haghighi Department of Psychology, Science and Arts University, Yazd, Iran 0000-0002-1308-2143 Mitra Ghadiri Department of Psychology, Faculty of Humanities, Science and Arts University, Yazd, Iran Fatemeh Nikafshan Department of Educational Psychology, Taft Branch, Payam Noor University, Yazd, Iran. Raha Shabanzadeh Department of Clinical Psychology, Faculty of Education and Psychology, Shahid Beheshti University, Tehran, Iran. 0000-0002-6025-960x Mohammad Hossein Zebhi Department of Psychology, Science and Arts University, Yazd, Iran 0000-0002-5699-4206 Journal Article 2022 02 16 <strong>Background and Aims</strong> Alzheimer’s disease (AD) is a common neurological disorder that begins with mild memory loss and progresses to severe impairment of executive and cognitive functions. This study aims to investigate the effect of repeated transcranial magnetic stimulation (rTMS) on the working memory of patients with AD.<br /><strong>Methods </strong>In this quasi-experimental study with a pre-test/post-test design, 30 patients with AD aged 55-75 years referred to neurology clinics in Yazd, Iran participated, who were selected using a convenience sampling method and divided into two groups of intervention (n=15) and control (n=15). Active memory was measured by a computerized n-back test, both in terms of reaction time and percentage of accuracy before and after treatment. In the control group, each patient received 10 sessions of inactive rTMS for 20 minutes, while the intervention group received 10 sessions of active rTMS for 20 minutes at a frequency of 10 Hz over the left dorsal lateral prefrontal cortex. Data analysis was performed using analysis of covariance.<br /><strong>Results </strong>Data analysis results showed that the reaction time significantly decreased, and the percentage of accuracy significantly increased in the n-back test in the intervention group after receiving rTMS compared to the control group (P= 0.001).<br /><strong>Conclusion </strong>It seems that rTMS over the left dorsal lateral prefrontal cortex can improve the working memory in patients with AD. <strong>Background and Aims</strong> Alzheimer’s disease (AD) is a common neurological disorder that begins with mild memory loss and progresses to severe impairment of executive and cognitive functions. This study aims to investigate the effect of repeated transcranial magnetic stimulation (rTMS) on the working memory of patients with AD.<br /><strong>Methods </strong>In this quasi-experimental study with a pre-test/post-test design, 30 patients with AD aged 55-75 years referred to neurology clinics in Yazd, Iran participated, who were selected using a convenience sampling method and divided into two groups of intervention (n=15) and control (n=15). Active memory was measured by a computerized n-back test, both in terms of reaction time and percentage of accuracy before and after treatment. In the control group, each patient received 10 sessions of inactive rTMS for 20 minutes, while the intervention group received 10 sessions of active rTMS for 20 minutes at a frequency of 10 Hz over the left dorsal lateral prefrontal cortex. Data analysis was performed using analysis of covariance.<br /><strong>Results </strong>Data analysis results showed that the reaction time significantly decreased, and the percentage of accuracy significantly increased in the n-back test in the intervention group after receiving rTMS compared to the control group (P= 0.001).<br /><strong>Conclusion </strong>It seems that rTMS over the left dorsal lateral prefrontal cortex can improve the working memory in patients with AD. https://medrehab.sbmu.ac.ir/article_1101692_85ccd3b8b683681614e834f8a9d2612d.pdf