تعیین اثر تمرین مقاومتی غیرخطی بر نشانگران بیوشیمیایی کبد در زنان یائسه دارای کبد چرب غیرالکلی

نوع مقاله : مقاله پژوهشی

نویسندگان

1 دانشجوی دکترای فیزیولوژی ورزش، دانشکده تربیت بدنی، دانشگاه آزاد اسلامی واحد تهران مرکز، تهران، ایران

2 استاد گروه فیزیولوژی ورزشی، دانشگاه آزاد اسلامی واحد تهران مرکزی، تهران، ایران

3 دکترای فیزیولوژی ورزش، دانشیار و هیأت علمی دانشکده تربیت بدنی، دانشگاه آزاد اسلامی واحد تهران مرکزی، تهران، ایران

4 دکترای فیزیولوژی ورزش، استادیار و هیأت علمی دانشکده تربیت بدنی، دانشگاه آزاد اسلامی واحد تهران مرکزی، تهران، ایران

چکیده

مقدمه و اهداف
گذار یائسگی با تغییرات نامطلوب در ترکیب بدن، توزیع چربی، افزایش چربی احشایی و شیوع کبد چرب غیرالکلی همراه است، اما مطالعات محدودی اثرات فعالیت بدنی را بر عملکرد کبد در دوران یائسگی بررسی نموده­اند. هدف از پژوهش حاضر، تعیین اثر تمرین مقاومتی غیرخطی بر سطوح آلانین آمینوترانسفراز، آسپارتات آمینو ترانسفراز، آلکالین فسفاتاز، گاما گلوتامیل ترانسفراز، بیلی روبین کل و پلاکت در زنان یائسه چاق مبتلا به کبد چرب غیرالکلی بود.
مواد و روش­ها
از میان زنان یائسه دارای کبد چرب غیرالکلی 60 تا 71 سال، 23 نفر به­طور تصادفی انتخاب و به دو گروه تمرین مقاومتی (12 نفر( و کنترل (11 نفر) تقسیم شدند. گروه تجربی 12 هفته، با شدت­های متفاوت تمرین مقاومتی انجام دادند و گروه کنترل زندگی روزمره عادی خود را ادامه دادند. نمونه­های خونی قبل و بعد از انجام پروتکل گرفته شد. تجزیه و تحلیل داده­ها با روش آماری ANCOVA یک راهه و t زوجی و نرم افزار SPSS 22 (05/0p<) انجام شد.
یافته­ها
 سطوح آلانین آمینوترانسفراز (013/0p=) و آسپارتات آمینوترانسفراز (000/0p=) در گروه تمرین مقاومتی به­طور قابل توجهی کاهش یافت، اما در گروه کنترل تغییر معناداری دیده نشد (05/0p>). سطوح آلکالین فسفاتاز، گاماگلوتامیل ترانسفراز، بیلی روبین کل و پلاکت در دو گروه تفاوت معناداری نداشت (05/0p>) و در گروه تمرین مقاومتی قدرت عضلانی بهبود یافت (000/0=p).
نتیجه­گیری
نتایج نشان داد که با افزایش سن، گذار یائسگی و بی­تحرکی، افزایش وزن و شیوع کبد چرب غیرالکلی مشهود است. این عوامل سلامت زنان در مرحله یائسگی را به خطر می­اندازد، اما تمرین مقاومتی غیرخطی برای بهبود عملکرد و قدرت عضلات مفید است. این امر می­تواند مورد توجه پزشکان، مربیان و طراحان برنامه­های تمرینی برای کاهش اثرات جانبی درمان­های دارویی قرارگیرد.

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

Effects of Nonlinear Resistance Training on Liver Biochemical Marker Levels in Postmenopausal Women with Nonalcoholic Fatty Liver Disease

نویسندگان [English]

  • Baharak Moradi Kelardeh 1
  • Mohammad Ali Azarbayjani 2
  • Maghsoud Peeri 3
  • Hasan Matin Homaee 4
1 PhD Student of Department of Exercise Physiology, Faculty of Physical Education, Central Tehran Branch, Islamic Azad University,Tehran, Iran.
2 Professor of Department of Exercise Physiology, Faculty of Physical Education, Central Tehran Branch, Islamic Azad University,Tehran, Iran.
3 Assistant Professor of Department of Exercise Physiology, Faculty of Physical Education, Central Tehran Branch, Islamic Azad University,Tehran, Iran.
4 Assistant Professor of Department of Exercise Physiology, Faculty of Physical Education, Central Tehran Branch, Islamic Azad University,Tehran, Iran.
چکیده [English]

Background and Aim: Menopause transition is accompanied with undesirable changes in body composition, fat distribution, increased visceral fat, and prevalence of nonalcoholic fatty liver disease. But limited studies have examined the effects of physical activity on liver function in post-menopausal climacteric. The purpose of the current study was to investigate the effects of nonlinear resistance training on levels of alanine aminotransfrase, aspartate aminotransfrase, alkaline phosphatase, Gamma-glutamyl transferase, total bilirubin, and platelet count in post-menopausal women with obesity and nonalcoholic fatty liver disease.
Materials and Methods: A total of 23 post-menopausal women with non-alcoholic fatty liver disease, between 60 to 71 years old, were randomly assigned to resistance training (n=12) and control (n=11) groups. The experimental group received 12-weeks of the resistance training with different intensities and the participants in control group continued their normal sedentary life. Blood samples were obtained before and after the protocol. Data was analyzed running one-way ANCOVA and paired t test using SPSS (version 22) (p<0.05).
Results: Alanine aminotransfrase (p=0.013) and aspartate aminotransferase (p=0.000) levels significantly decreased in resistance training group but not in control group (p>0.05). Alkaline phosphatase, Gamma-glutamyl transferase, total bilirubin, and platelet counts did not significantly change in the two groups (p>0.05), while muscle strength was improved in resistance training group (p=0.000).
Conclusion: The results showed that with aging, menopausal transition, inactivity, weight gaining, and prevalence of non-alcoholic fatty liver disease were evident. These factors would endanger the health of post-menopausal women. But nonlinear resistance training is helpful to improve liver function and muscle strength. These findings can be helpful for physicians, coaches, and designers of training plans to reduce the side effects of drug therapy.
 
 

کلیدواژه‌ها [English]

  • menopause
  • Non-linear resistance training
  • Liver
  • Muscle strength
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