Effects of Nonlinear Resistance Training on Liver Biochemical Marker Levels in Postmenopausal Women with Nonalcoholic Fatty Liver Disease

Document Type : Original article

Authors

1 PhD Student of Department of Exercise Physiology, Faculty of Physical Education, Central Tehran Branch, Islamic Azad University,Tehran, Iran.

2 Professor of Department of Exercise Physiology, Faculty of Physical Education, Central Tehran Branch, Islamic Azad University,Tehran, Iran.

3 Assistant Professor of Department of Exercise Physiology, Faculty of Physical Education, Central Tehran Branch, Islamic Azad University,Tehran, Iran.

Abstract

Background and Aim: Menopause transition is accompanied with undesirable changes in body composition, fat distribution, increased visceral fat, and prevalence of nonalcoholic fatty liver disease. But limited studies have examined the effects of physical activity on liver function in post-menopausal climacteric. The purpose of the current study was to investigate the effects of nonlinear resistance training on levels of alanine aminotransfrase, aspartate aminotransfrase, alkaline phosphatase, Gamma-glutamyl transferase, total bilirubin, and platelet count in post-menopausal women with obesity and nonalcoholic fatty liver disease.
Materials and Methods: A total of 23 post-menopausal women with non-alcoholic fatty liver disease, between 60 to 71 years old, were randomly assigned to resistance training (n=12) and control (n=11) groups. The experimental group received 12-weeks of the resistance training with different intensities and the participants in control group continued their normal sedentary life. Blood samples were obtained before and after the protocol. Data was analyzed running one-way ANCOVA and paired t test using SPSS (version 22) (p<0.05).
Results: Alanine aminotransfrase (p=0.013) and aspartate aminotransferase (p=0.000) levels significantly decreased in resistance training group but not in control group (p>0.05). Alkaline phosphatase, Gamma-glutamyl transferase, total bilirubin, and platelet counts did not significantly change in the two groups (p>0.05), while muscle strength was improved in resistance training group (p=0.000).
Conclusion: The results showed that with aging, menopausal transition, inactivity, weight gaining, and prevalence of non-alcoholic fatty liver disease were evident. These factors would endanger the health of post-menopausal women. But nonlinear resistance training is helpful to improve liver function and muscle strength. These findings can be helpful for physicians, coaches, and designers of training plans to reduce the side effects of drug therapy.
 
 

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References

  1. Prestes J, Shiguemoto G, Botero JP, Frollini A, Dias R, Leite R, Pereira G Magosso R, Baldissera V, Cavaglieri C, Perez S. Effects of resistance training on resistin, leptin, cytokines, and muscle force in elderly post-menopausal women. J Sports Sci 2009 ; 3: 1 – 9.##
  2. Hashimoto E, Tokushige K. Prevalence, gender, ethnic variations, and prognosis of NASH. Am J Gastroenterol. 2011; 46(1): 63–69.##
  3. OkanoueTA, Umemura K, Yasui S, Itoh Y. Nonalco-holic fatty liver disease and nonalcoholic steatohepatitis in Japan. Eur J Gastroenterol Hepatol. 2011; 26(1): 153–162.##
  4. Volzke H, Schwarz S, Baumeister SE, Wallaschofski H, schwahn C, Jorgen Grabe H, Doren M. Menopausal status and hepatic steatosis in a general female population. Gut 2007;56:594-595.##
  5. Suzuki A, Abdelmalek MF. Nonalcoholic fatty liver disease in women.J Womens Health 2009; 5 : 191-203.
  6. Pighon A, Barsalani R, Yasari S, Prud homme D, Lavoie JM. Does exercise training prior to ovariectomy protect against liver and adipocyte fat accumulation in rats? Climacteric 2010 ; 13 : 238 – 248.##
  7. Stefanick ML, Anderson GL, Margolis KL, Hendrix SL, Rodabough RJ, Paskett ED, Lane DS, Hubbell FA, Assaf AR, Sarto GE, Schenken RS, Yasmeen S, Lessin L, Chlebowski RT, WHI Investigators . Effects of conjugated equineestrogens on breast cancer and mammography screening in postmenopausal women with hysterectomy. JAMA 2006; 295: 1647 – 1657.##
  8. Bellentani S, Bedogni G, Miglioli L, Tiribelli C. The epidemiology of fatty liver. Eur J Gastroenterol Hepatol. 2004; 16(11): 1087–1093.##
  9.  Schmucker DL. Age-related changes in liver structure and function: Implications for disease? Exp Geront. 2005; 40(9): 650–659.##
  10. Bhat G, Baba CS, Pandey A, Kumari N, Choudhuri G. Life style modification improves insulin resistance and liver histology in patients with nonalcoholic fatty liver disease. World J Hepatol. 2012; 4(7): 209-217.##
  11. Fattakhova G, Hollingsworth KG, Thoma C, Moore S, Taylor R, Day CP, Trenell MI. Resistance exercise reduces liver fat and its mediators in non-alcoholic fatty liver disease independent of weight loss. Gut 2011; 60(9):1278-1283.##
  12. Benjamin K, Carson BG, Carson RG. The consequences of resistance training for movement control in older adults. J Gerontol A Biol Sci Med Sci. 2004 ; 59 : 730 – 754.##
  13. Fleck, SJ. Non-linear periodization for general fitness & athletes. J Hum Kinet. 2011; 29: 41–45.##
  14. Brzycki,M. Strength testing-predicting a one-rep max from rep-to-fatigue. JOPERD. 1993; 68: 88-90.##
  15. Nikseresht M, Agha-Alinejad H, Azarbayjani MA, Ebrahim K. Effects of nonlinear resistance and aerobic interval training on cytokines and insulin resistance in sedentary men who are obese. J Strength Cond Res. 2014 Sep;28(9):2560-8.##
  16. Kraemer, WJ and Fleck, SJ.Optimizing Strength Training: Designing Nonlinear Periodization Workouts. Champaign, Illinois: Human Kinetics Publishing, 2007.##
  17. Damor K, Mittal K, Bhalla AS, Sood R, Pandey RM, Guleria R, Luthra K, Vikram NK. Effect of progressive resistance exercise training on hepatic fat in asian indians with non-alcoholic fatty liver disease. Br J Med Med Res. 2014; 4(1): 114-124. ##
  18. Leite RD, Prestes J, Bernardes CF, Shiguemoto GE, Pereira GB, Duarte JO Domingos MM, Baldissera V, De Andrade Perez SE. Effects of ovariectomy and resistance training on lipid content in skeletal muscle, liver and heart; fat depots; and lipid profile. Appl Physiol Nutr Metab 2009, 34: 1079-1086. ##
  19. Alie M, Matinhommaee H, Azarbayjani MA, Peeri M. The effect of resistance training intensity on enzymatic and nonenzymatic markers of liver function in obese males. Ind. J. Fund. Appl Life Sci. 2015; 5(2):101-110.##
  20. Slentz CA, Bateman LA, Willis LH, Shields AT, Tanner CJ, Piner LW, Hawk VH, Muehlbauer MJ, Samsa GP, Nelson RC, Huffman KM, Bales CW, Houmard JA, Kraus WE. Effects of aerobic vs. resistance training on visceral and liver fat stores, liver enzymes, and insulin resistance by HOMA in overweight adults from STRRIDE AT/RT. Am J Physiol Endocrinol Metab. 2011; 301(5): 1033-1039. ##
  21. Sigal R, Kenny G, Boule N, Wells G, Prud’homme D, Fortiere M, Reid R, Tulloch H, Coyle D, Phillips P, Jennings A, Jaffey J. Effects of aerobic training, resistance training or both on glycemic control in type 2. diabetes. Ann Intern Med.2007; 147: 357–369.##
  22. Bacchi E, Negri C, Targher G, Faccioli N, Lanza M, Zoppini G, Zanolin E, Schena F, Bonora E, Moghetti P. Both resistance training and aerobic training reduce hepatic fat content in type 2 diabetic subjects with nonalcoholic fatty liver disease (the RAED2 Randomized Trial). Hepatology. 2013; 58(4):1287-1295. ##
  23. Alie M, Matinhommaee H, Azarbayjani MA, Peeri M. The effect of resistance exercise intensity on enzymetic and non enzymetic markers of function in obese men. Ind. J. Fund. Appl Life Sci. 2015 ;. 5 (2) :101-110.##
  24. Treuth MS, Hunter GR, Weinsier RL, Kell SH. Energy expenditure and substrate utilization in older women after strength training: 24-h calorimeter results. J Appl Physiol. 1995 ;78(6):2140-2146.##
  25. Strasser B, Schobersberger W. Evidence for resistance training as a treatment therapy in obesity. J Obes Article. 2011; 9 pages. ID 482564, doi:10.1155/2011/482564.##
  26. Park GJ, Lin BP, Ngu MC, Jones DB, Katelaris PH. Aspartate aminotransferase: alanine aminotransferase ratio in chronic hepatitis C infection: is it a useful predictor of cirrhosis? JGastroenterol Hepatol 2000; 5(4):386-390.##
  27. Mougios, V. Exercise Biochemistry. Champaign, IL: Human Kinetics, 2006.##
  28. Rowell LB, Blackmon JR, Bruce RA. Indocyanine green clearance and estimated hepatic blood flow during mild to maximal exercise in upright men. J Clin Invest. 1964;43:1677-1690.##
  29. Wannamethee SG, Gordon DO, Peter H, Rumley WA, Walker M, Lennon L. Physical activity and hemostatic and inflammatory variables in elderly men. Circulation. 2002; 105: 1785-1790. ##
  30.        29. Bobeuf F, Labonte M, Khalil A, Dionne IJ. Effect of resistance training on hematological blood markers in older men and women: A pilot study. Curr Gerontol Geriatr Res2009; 4 pages. Article ID 156820. doi:10.1155/2009/156820.##
  31. Rezaee M, Soleimani M, Hasanshahi M, Ebrahimi F, Ebrahimi M, Nemati A, mohamad nejad A, Naderi E. Comparison effect of three methods of resistance, endurance and concurrent exercises on coagulation markers and serum lipid profile of non-athlete male collage students. IJSS. 2014; 4 (7), 848-854.##
  32. Gaeinei AA. Developmental exercise physiology. 1th ed. Tehran: danesh afroz. 2000; p: 288-292.[In Persian]##             
  33. Suzuki A, Abdelmalek MF. Nonalcoholic fatty liver disease in women. Res J Women,s Health. 2009; 5(2): 191-203.##
  34. Frith J, Jones D, Newton JL. Chronic liver disease in an ageing population. Age and Ageing. 2009; 38(1):11-18.##
The Scientific Journal of Rehabilitation Medicine
Volume 5, Issue 4
January and February 2017
Pages 136-145

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History

  • Receive Date: 24 November 2015
  • Revise Date: 23 February 2016
  • Accept Date: 05 March 2016
  • First Publish Date: 21 December 2016

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