The Effect of Resistance Training and Vitamin D Supplementation on Fibroblast Growth Factor 23 and Klotho Protein in Male Rats with Renal Failure

Document Type : Original article

Authors

1 Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran

2 Assistant Professor, Department of Exercise Physiology, Science and Researches Branch, Islamic Azad University, Tehran, Iran.

3 Department of Physical Education and Sport Sciences, Shahid Beheshti University, Tehran, Iran

Abstract

Background and Aims: Considering the effective role of exercise as a complementary therapy in kidney patients and also due to vitamin D deficiency in kidney patients and the effect of this deficiency on disease progression, the present study was designed to compare the effects of eight weeks of resistance training with vitamin D supplementation on FGF23 and Klotho protein levels in male rats with chronic kidney disease.

Materials and Methods: Sixteen male Wistar rats (weigh: 350-370 g) were divided into four groups (n:4): training, supplementation, training and supplemention and control group. After induction of kidney damage through NX 5.6 surgical method and two weeks recovery, eight weeks of resistance training with different percentages of body weight, 3 sessions per week every other day were performed. Simultaneously, 1000 unit of vitamin D per week intramuscularly (quadriceps femoris muscle) was injected.

Results: The results related to FGF-23 data showed a significant decrease after eight weeks between the control group with resistance training group (P=0.001) and the supplemention with resistance training group (P=0.043); However, there was no significant difference in the amount of FGF-23 between the control and vitamin D group (P>0.05). Also, no significant difference was observed between the training group with supplementation and the resistance training group (P>0.05). The results of Klotho protein showed that the increase in Klotho protein was significant between the control group with supplement (P=0.000), resistance training (P=0.006) and supplement with resistance training (P=0.001) groups. There was no significant difference between the training group with supplement with the two groups of supplementation and resistance training alone (P>0.05).

Conclusion It can be concluded that, eight weeks of resistance training alone and in combination with vitamin D caused a significant decrease in FGF-23 levels and also increased the amount of Klotho protein; but there was no significant difference in the combination of exercise and supplementation with other groups. Apparently, this type of exercise can play an effective role in controlling the progression and treatment of of rats with kidney disease, although more research is needed to make a definitive statement.

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The Scientific Journal of Rehabilitation Medicine

Articles in Press, Accepted Manuscript
Available Online from 08 January 2022

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History

  • Receive Date: 10 November 2021
  • Revise Date: 26 December 2021
  • Accept Date: 29 December 2021
  • First Publish Date: 08 January 2022

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