تأثیر تمرین استقامتی بر مقادیر آلانین آمینوترانسفراز، آسپارتات آمینوترانسفراز و رزیستین سرم در مردان مبتلا به بیماری کبد چرب غیرالکلی

نوع مقاله : مقاله پژوهشی

نویسندگان

1 دانشجوی دکتری فیزیولوژی ورزشی، گروه تربیت بدنی و علوم ورزشی، دانشکده علوم تربیتی و روان شناسی، دانشگاه محقق اردبیلی، اردبیل، ایران

2 استاد فیزیولوژی ورزشی، گروه تربیت بدنی و علوم ورزشی، دانشکده علوم تربیتی و روانشناسی، دانشگاه محقق اردبیلی، اردبیل، ایران

3 دانشیار بیماری‏ های داخلی، دانشکده پزشکی، دانشگاه علوم پزشکی و خدمات بهداشتی درمانی اردبیل، اردبیل، ایران

4 استادیار فیزیولوژی ورزشی، گروه تربیت بدنی و علوم ورزشی، دانشکده علوم تربیتی و روانشناسی، دانشگاه محقق اردبیلی، اردبیل، ایران

5 استادیار گروه رادیولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی و خدمات بهداشتی درمانی اردبیل، اردبیل، ایران

چکیده

مقدمه و اهداف
بیماری کبد چرب غیرالکلی یک مشکل سلامت عمومی در جهان به شمار می‏رود. فعالیت ورزشی نخستین خط درمانی برای افراد مبتلا به بیماری کبد چرب غیرالکلی است؛ بنابراین، پژوهش حاضر به منظور بررسی تأثیر هشت هفته تمرین استقامتی بر مقادیر سرمی آنزیم‏های کبدی آلانین آمینوترانسفراز، آسپارتات آمینوترانسفراز و رزیستین سرم در مردان مبتلا به کبد چرب غیرالکلی انجام شد.
مواد و روش ‏ها
در مطالعه نیمه‏تجربی حاضر، 23 نفر از بیماران مبتلا به بیماری کبد چرب غیرالکلی به صورت هدفمند انتخاب شدند. افراد مورد مطالعه به صورت تصادفی در دو گروه تمرین استقامتی (12 نفر) و کنترل (11 نفر) قرار گرفتند. برنامه تمرین استقامتی شامل هشت هفته تمرین با شدت متوسط 60 تا 75 درصد حداکثر ضربان قلب به مدت 45 دقیقه در هر جلسه و سه بار در هفته بود. قبل از شروع پژوهش و در پایان هفته هشتم از تمامی افراد خون­گیری به عمل آمد. داده‏ها با استفاده از آزمون‏های آماری شاپیرو-ویلک، t ‏زوجی و t مستقل در سطح معناداری 05/0>α تجزیه و تحلیل شد.
یافته ‏ها
در پژوهش حاضر، هشت هفته تمرین استقامتی به کاهش معنا‏دار مقادیر سرمی آلانین آمینوترانسفراز، آسپارتات آمینوترانسفراز و رزیستین در مردان مبتلا به بیماری کبد چرب غیرالکلی منجر شد(05/0>α).
نتیجه‏ گیری
تمرین استقامتی احتمالاً باعث بهبود مقادیر سرمی آلانین آمینوترانسفراز، آسپارتات آمینوترانسفراز و رزیستین در مردان مبتلا به بیماری کبد چرب غیرالکلی شود؛ لذا در راستای کاهش عوامل خطر وابسته به بیماری کبد چرب غیرالکلی مداخله درمانی مفیدی است.

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

Effect of Endurance Training on Serum Levels of Alanine Aminotransferase, Aspartate Aminotransferase, and Resistin in Men with Non-Alcoholic Fatty Liver Disease

نویسندگان [English]

  • Asghar Mahmoudi 1
  • Marefat Siahkohian 2
  • Manuchehr Iranparvar 3
  • Farnaz Seifi-Skishahr 4
  • Hasan Anari 5
1 PhD Candidate of Exercise Physiology, Department of Physical Education and Sport Sciences, Faculty of Education and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran
2 Professor of exercise physiology, Department of Physical Education and Sport Sciences, Faculty of Education and Psychology, Univercity of Mohaghegh Ardabili, Ardabil, Iran
3 Associate Professor, Department of Internal Diseases, Ardabil University of Medical Sciences, Ardabil, Iran.
4 Assistant Professor, Department of Physical Education and Sport Sciences, Faculty of Education and Psychology , Univercity of Mohaghegh Ardabili, Ardabil, Iran.
5 Assistant Professor, Department of Radiology, Ardabil University of Medical Sciences, Ardabil, Iran
چکیده [English]

Background and Aims: Non-alcoholic fatty liver disease is a public health problem in the world. Exercise is a first-line therapy for patients with non-alcoholic fatty liver disease. Therefore, the present study was conducted to determine the effect of eight weeks of endurance training on serum levels of alanine aminotransferase, aspartate aminotransferase, and resistin in men with non-alcoholic fatty liver disease.
Materials and Methods: A total of 23 patients with non-alcoholic fatty liver disease were selected following purposeful sampling in the present quasiexperimental study. Participants were randomly divided into two groups: endurance training group (n=12) and control group (n=11). The endurance training program included moderate intensity training with 60-75% of maximal heart rate for 45 min/session, 3 times/week for 8 weeks. At both baseline and completion of the eighth week, blood samples were obtained from all the participants. Data were analyzed running Shapiro-Wilk test and dependent and independent t-tests at the significant level of pResults: In the current study, eight weeks of endurance training resulted in a significant decrease in serum levels of alanine aminotransferase, aspartate aminotransferase, and resistin in males with non-alcoholic fatty liver(α<0.05).
Conclusion: According to the findings, endurance training may improve the serum levels of alanine aminotransferase, aspartate aminotransferase, and resistin in men with non-alcoholic fatty liver disease. Therefore, to reduce the dependent risk factors of non-alcoholic fatty liver disease, this therapeutic intervention seems to be beneficial.

کلیدواژه‌ها [English]

  • Nonalcoholic fatty liver disease
  • Endurance training
  • Transaminases
  • Resistin
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