نوع مقاله : مقاله پژوهشی
نویسندگان
1 دانشکده تربیت بدنی و علوم ورزشی، دانشگاه آزاد اسلامی واحد علوم و تحقیقات تهران ایران
2 دانشکده تربیت بدنی و علوم ورزشی، واحد علوم تحقیقات تهران، دانشگاه آزاد اسلامی، تهران، ایران.
3 دانشکده تربیت بدنی و علوم ورزشی، دانشگاه شهید بهشتی، تهران، ایران
4 دانشکده تربیت بدنی و علوم ورزشی، دانشگاه آزاد اسلامی واحد علوم و تحقیقات، تهران، ایران
چکیده
کلیدواژه‌ها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
Background and Aims: Considering the effective role of exercise as a complementary therapy in kidney patients and also due to vitamin D deficiency in kidney patients and the effect of this deficiency on disease progression, the present study was designed to compare the effects of eight weeks of resistance training with vitamin D supplementation on FGF23 and Klotho protein levels in male rats with chronic kidney disease.
Materials and Methods: Sixteen male Wistar rats (weigh: 350-370 g) were divided into four groups (n:4): training, supplementation, training and supplemention and control group. After induction of kidney damage through NX 5.6 surgical method and two weeks recovery, eight weeks of resistance training with different percentages of body weight, 3 sessions per week every other day were performed. Simultaneously, 1000 unit of vitamin D per week intramuscularly (quadriceps femoris muscle) was injected.
Results: The results related to FGF-23 data showed a significant decrease after eight weeks between the control group with resistance training group (P=0.001) and the supplemention with resistance training group (P=0.043); However, there was no significant difference in the amount of FGF-23 between the control and vitamin D group (P>0.05). Also, no significant difference was observed between the training group with supplementation and the resistance training group (P>0.05). The results of Klotho protein showed that the increase in Klotho protein was significant between the control group with supplement (P=0.000), resistance training (P=0.006) and supplement with resistance training (P=0.001) groups. There was no significant difference between the training group with supplement with the two groups of supplementation and resistance training alone (P>0.05).
Conclusion It can be concluded that, eight weeks of resistance training alone and in combination with vitamin D caused a significant decrease in FGF-23 levels and also increased the amount of Klotho protein; but there was no significant difference in the combination of exercise and supplementation with other groups. Apparently, this type of exercise can play an effective role in controlling the progression and treatment of of rats with kidney disease, although more research is needed to make a definitive statement.
کلیدواژه‌ها [English]
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